Scientific publications

Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPAR Agonists.

Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, Everard A, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Delzenne NM, de Vos WM, Di Marzo V, Cani PD.
Cells. 2021 Jan 19;10(1):185.

Toxicological safety evaluation of pasteurized Akkermansia muciniphila.

Druart C, Plovier H, Van Hul M, Brient A, Phipps KR, de Vos WM, Cani PD.
Journal of Applied Toxicology. 2021 Feb;41(2):276-290.

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Paone P, Cani PD.
Gut. 2020 Dec;69(12):2232-2243.

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice

Depommier C, Van Hul M, Everard A, Delzenne NM, De Vos WM, Cani PD.
Gut Microbes. 2020 Sep 2;11(5):1231-1245.

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne NM, de Barsy M, Loumaye A, Hermans MP, Thissen JP, de Vos WM, Cani PD.
Nature Medicine. 2019 Jul;25(7):1096-1103.

Human gut microbiome: hopes, threats and promises.

Cani P.D.
Gut. 2018 Sep;67(9):1716-1725.

Gut microbiota — at the intersection of everything?

Cani PD.
Nature Reviews Gastroenterology & Hepatology. 2017 Jun;14(6):321-322.

Next-Generation Beneficial Microbes : The case of Akkermansia muciniphila.

Cani PD, de Vos WM.
Frontiers in Microbiology. 2017 Sep 22;8:1765.

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD.
Nature Medicine. 2017 Jan;23(1):107-113.

Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.

Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L; MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Doré J, Cani PD, Clément K.
Gut. 2016 Mar;65(3):426-36

Metabolism in 2013: The gut microbiota manages host metabolism.

Cani PD.
Nature Reviews Endocrinology. 2014 Feb;10(2):74-6.

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.

Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD.
Proceedings of the National Academy of Sciences of the United States of America. 2013 May 28;110(22):9066-71.

Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium.

Derrien M. et al., Vaughan EE, Plugge CM, de Vos WM.
International Journal of Systematic and Evolutionary Microbiology. 2004 Sep;54(Pt 5):1469-1476.